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KMID : 0352720110350030344
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Journal of Ginseng Research
2011 Volume.35 No. 3 p.344 ~ p.351
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Biotransformation of Ginsenoside Rb1 to Prosapogenins, Gypenoside XVII, Ginsenoside Rd, Ginsenoside F2, and Compound K by Leuconostoc mesenteroides DC102
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Quan Lin-Hu
Piao Jin-Ying
Min Jin-Woo
Kim Ho-Bin
Kim Sang-Rae
Yang Dong-Uk
Yang Deok-Chun
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Abstract
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Ginsenoside Rb1is the main component in ginsenosides. It is a protopanaxadiol-type ginsenoside that has a dammarane-type triterpenoid as an aglycone. In this study, ginsenoside Rb1 was transformed into gypenoside XVII, ginsenoside Rd, ginsenoside F2 and compound K by glycosidase from Leuconostoc mesenteroides DC102. The optimum time for the conversion was about 72 h at a constant pH of 6.0 to 8.0 and the optimum temperature was about 30°C. Under optimal conditions, ginsenoside Rb1 was decomposed and converted into compound K by 72 h post-reaction (99%). The enzymatic reaction was analyzed by highperformance liquid chromatography, suggesting the transformation pathway: ginsenoside Rb1→ gypenoside XVII and ginsenoside Rd→ginsenoside F2→compound K.
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KEYWORD
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Biotransformation, Gypenoside XVII, Ginsenoside Rd, Compound K, Leuconostoc mesenteroides DC102,
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